Journal: The Journal of pediatrics

Article Title: Higher Dose Noninvasive Transcutaneous Auricular Vagus Nerve Stimulation Increases Feeding Volumes and White Matter Microstructural Complexity in Open-Label Study of Infants Slated for Gastrostomy Tube

doi: 10.1016/j.jpeds.2023.113563

Figure Lengend Snippet: Change in mean daily PO feeding volumes for all 2x and 1x infants before and during taVNS-paired feeding treatment (n = 35). Responders who attained full oral feeds (n = 19) and nonresponders who received a G-tube (n = 16) did not differ in the number of taVNS treatments, average current intensity, or total pulses over all treatments (Table I). The analysis includes feeding data for the 1x taVNS group from our previous report.31

Article Snippet: Responders were defined as participants who were able to achieve and maintain full daily per os (PO) intake (>120 ml/kg/day) with weight gain adequate for discharge (>20 g/day); Infants who received G-tubes for inadequate oral intake after taVNS treatment were classified as nonresponders. . Transcutaneous Auricular Vagus Nerve—Paired Feeding Protocol We delivered taVNS using a constant current electronic pulse generator (Digitimer DS7AH, Digitimer LTD; or Soterix taVNS EPG, Soterix Medical Inc) with a custom-designed neonatal ear electrode placed at the anterior wall of the ear canal (anode, inner tragus) and an adhesive hydrogel electrode (Micro Neolead, Neotech Products) targeting the outside of the tragus (cathode) (Figure 1).

Techniques:

Journal: The Journal of pediatrics

Article Title: Higher Dose Noninvasive Transcutaneous Auricular Vagus Nerve Stimulation Increases Feeding Volumes and White Matter Microstructural Complexity in Open-Label Study of Infants Slated for Gastrostomy Tube

doi: 10.1016/j.jpeds.2023.113563

Figure Lengend Snippet: Change in DKI in specific WM tracts before and after taVNS-paired feeding. Upper panel: The study-specific FA template in Johns Hopkins University (JHU) atlas space created with modified tract based spatial statistics pipeline, overlaid with the green FA > 0.12 skeleton mask. Voxels of the mask within each region of interest were used in averaging each diffusivity or kurtosis metric. The CSTcp are denoted in blue and red and the EC, light-blue. Lower panel: K⊥ (mean, SEM) in nonresponders (n = 11) vs infants who attained full feeds (responders, n = 9) in the right CSTcp per week of development, and right EC. The increase in mean fractional anisotropy per week of development in the responders in the right superior longitudinal fasciculus showed a strong trend vs nonresponders. SLF, superior longitudinal fasciculus.

Article Snippet: Responders were defined as participants who were able to achieve and maintain full daily per os (PO) intake (>120 ml/kg/day) with weight gain adequate for discharge (>20 g/day); Infants who received G-tubes for inadequate oral intake after taVNS treatment were classified as nonresponders. . Transcutaneous Auricular Vagus Nerve—Paired Feeding Protocol We delivered taVNS using a constant current electronic pulse generator (Digitimer DS7AH, Digitimer LTD; or Soterix taVNS EPG, Soterix Medical Inc) with a custom-designed neonatal ear electrode placed at the anterior wall of the ear canal (anode, inner tragus) and an adhesive hydrogel electrode (Micro Neolead, Neotech Products) targeting the outside of the tragus (cathode) (Figure 1).

Techniques: Modification

Journal: The Journal of pediatrics

Article Title: Higher Dose Noninvasive Transcutaneous Auricular Vagus Nerve Stimulation Increases Feeding Volumes and White Matter Microstructural Complexity in Open-Label Study of Infants Slated for Gastrostomy Tube

doi: 10.1016/j.jpeds.2023.113563

Figure Lengend Snippet: Mean kurtosis images obtained pre-taVNS treatment and the binomial logistic regression model fit for the probability of achieving of full feeds (responder = 1, non-responder = 0) with paired-taVNS. MK in CSTcp before taVNS identifies infants who achieve full oral feeds. Independent variables were MK averages of both left (P = .028) and right (P = .027) CSTcp, adjusted for IDM status (P = .025).

Article Snippet: Responders were defined as participants who were able to achieve and maintain full daily per os (PO) intake (>120 ml/kg/day) with weight gain adequate for discharge (>20 g/day); Infants who received G-tubes for inadequate oral intake after taVNS treatment were classified as nonresponders. . Transcutaneous Auricular Vagus Nerve—Paired Feeding Protocol We delivered taVNS using a constant current electronic pulse generator (Digitimer DS7AH, Digitimer LTD; or Soterix taVNS EPG, Soterix Medical Inc) with a custom-designed neonatal ear electrode placed at the anterior wall of the ear canal (anode, inner tragus) and an adhesive hydrogel electrode (Micro Neolead, Neotech Products) targeting the outside of the tragus (cathode) (Figure 1).

Techniques: